Acid-Base Balance in Uremic Rats with Vascular Calcification

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Acid-Base Balance in Uremic Rats with Vascular Calcification

BACKGROUND/AIMS Vascular calcification (VC), a major complication in humans and animals with chronic kidney disease (CKD), is influenced by changes in acid-base balance. The purpose of this study was to describe the acid-base balance in uremic rats with VC and to correlate the parameters that define acid-base equilibrium with VC. METHODS Twenty-two rats with CKD induced by 5/6 nephrectomy (5/...

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Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification.

Vascular calcification (VC) is a critical complication in patients with chronic kidney disease (CKD). The effects of spironolactone (SPL), a mineralocorticoid receptor (MR) antagonist, on VC have not been fully investigated in CKD. The present in vivo study determined the protective effects of SPL on VC in CKD rats. Rats were divided into a control group and four groups of rats with adenine-ind...

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Differential effects of vitamin D receptor activators on vascular calcification in uremic rats.

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ژورنال

عنوان ژورنال: Nephron Extra

سال: 2014

ISSN: 1664-5529

DOI: 10.1159/000363298